Yeying Chen | ALES Graduate Seminar

Date(s) - 14/12/2023
9:00 am - 10:00 am

A graduate exam seminar is a presentation of the student’s final research project for their degree.
This is an ALES MSc Course-Based Final Exam Seminar by Yeying Chen. This seminar is open to the general public to attend:
Meeting ID: 953 2526 6050 Passcode: 118706

Topic: Do Adults with Diabetic Kidney Disease Meet Canadian Habitual Physical Activity Guidelines?

MSc with Dr. Diana Mager.

Seminar Abstract:

Introduction: Diabetic kidney disease (DKD) is a long-lasting complication of Diabetes Mellitus (DM). High Habitual Physical activity (HPA) levels and low Sedentary behaviour (SB) have been proven to be associated with positive, health outcomes in adults with DKD. Canadian Physical Activity (CPA) Guidelines set recommended HPA values for healthy populations in different age groups. The study objective was to compare the recommended HPA level set by the CPA and the HPA levels of non-frail DKD adults, to study the associations of HPA with markers of cardiometabolic dysregulation, CKD stage, and body composition, and to determine the statistical agreement between International Physical Activity Questionnaire (IPAQ) and pedometer.

Methods: This study was a secondary analysis of baseline data of an ongoing RCT (Fantastic study PRO00089513). The analysis recruited non-frail adults (58 -80 yrs; n=24) and collected their HPA data at baseline using the IPAQ and Fitbit Inspire® accelerometer. Demographic, anthropometric (BMI), laboratory (hemoglobin A1C [HbA1C], estimated glomerular filtration rate [eGFR]) and body composition data (fat mass [FM], lean mass [LM]) were included.

Results: Participants had an average age of 67±5.5, and 78% had CKD stage 1-2 (n=18). The average MVPA/min (IPAQ) was 622±794min/wk, significantly higher than MVPA/min CPA guidelines (p=0.008). Fitbit reported an SB of 13±2hr/d, significantly longer than SB/hr CPA guidelines (p<0.001). MVPA≥150 min/wk (IPAQ) was significantly associated with a lower prevalence of adverse stage of CKD vs MVPA<150 min/wk (81%vs71%, p=0.0003). SB<8hr/d (IPAQ) was associated with significantly lower FM (p=0.04) and higher LM (p=0.04) vs SB≥8hr/d.  No other associations between HPA and demographic and laboratory markers were observed. There was a significant mean difference (p<0.001) between MVPA recorded by the IPAQ and Fitbit with a correlation r=0.838. Aland Altman plot revealed the statistical agreement between the SB of the two tools (r=0.268, p=0.217).

Conclusion: The SB and MVPA of non-frail DKD patients in the control group were significantly higher than and similar to the recommendations of the CPA Guidelines, respectively. High HPA was associated with a lower CKD stage, higher LM, and lower FM. The SB data produced by Fitbit were statistically consistent with the IPAQ while MVPA data of them were not.