Maryah Robinson-Jackson | ALES Graduate Seminar

Date(s) - 14/04/2022
9:00 am - 10:00 am

A graduate exam seminar is a presentation of the student’s final research project for their degree.
This is an ALES MSc course-based seminar by Maryah Robinson-Jackson. This seminar is open to the general public to attend.
Meeting ID: 919 0902 7649 | Passcode: 997350 |
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Project Topic: The Effect of a Home-Based 6-Month Lifestyle Intervention on Functional Outcomes in Older Adults with Type 2 Diabetes and Chronic Kidney Disease (FANTASTIC)

MSc with Dr. Diana Mager.

Seminar Abstract:

Background: Older adults with type 2 diabetes (T2D) and chronic kidney disease (CKD) often experience coinciding frailty. Frailty is a complex, multifactorial condition marked by increased physiological and psychological vulnerability, deterioration in physical functioning and decreased cognition and mental state. The FANTASTIC study aims to understand the impact that a 6-month home-based lifestyle intervention (exercise, nutrition literacy) has on frailty outcomes (frailty status, measures of muscle strength, physical performance, body composition) and other clinical outcomes (measures of activities of daily living in [ADL], nutrition literacy, diet quality, mental health and cognition) in community dwelling, older adults with T2D and CKD (stages I-IV).

Methods: Participants (n=45; 67.0 ±7.6 years) were recruited from Alberta Kidney Care North Clinics. Participants were screened for frailty (Clinical Frailty Index) and then randomized into the intervention (frail n=7; non-frail n=15) or standard of care (frail n= 7; non-frail n=16) group. Participants underwent frailty (Edmonton Frail Scale [EFS], Short Physical Performance Battery [SPPB]), muscle strength (Hand-grip), nutrition literacy (Nutrition Literacy Scale), ADL (Modified Barthel Index), mental health (Major Depression Inventory [MDI]) and body composition (DEXA) assessments at baseline and six months. Resistance exercise (3x weekly) and nutrition literacy (twice monthly) education was provided using digital technology throughout the 6-month intervention.

Results: Following the 6-month intervention frail intervention group participants experienced significant improvements (% change) in functional (SPPB sit-to-stand [50%]), frailty (EFS [-22.5%]), muscle strength (hand-grip right [24%] and left [18%]) and mental health (MDI [29%]) outcomes (p<0.05). The improvement in EFS score percent change was significantly greater for intervention frail participants compared to intervention non-frail (p<0.05). No significant changes in nutrition literacy, body composition or ADL measures were observed (p>0.05).

Conclusion: Preliminary results from this RCT illustrate that a six-month resistance exercise and nutrition literacy program result in significant improvements in measures of frailty, functional status and muscle strength, but not in nutrition literacy, body composition and ADL measures in community dwelling older adults with T2D and CKD.