Chelsea Kamprath | ALES Graduate Seminar

Date(s) - 17/03/2022
9:00 am - 10:00 am

A graduate exam seminar is a presentation of the student’s final research project for their degree.
This is an ALES MSc Final Exam Seminar by Chelsea Kamprath. This seminar is open to the general public to attend.
Meeting ID: 946 9599 4702 | Passcode: 175731
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Thesis Topic: The impact of a six-month home-based resistance exercise program in adults with type 2 diabetes and chronic kidney disease on muscle function, frailty status, health related quality of life and health literacy

MSc with Dr. Diana Mager.

Seminar Abstract:

Background: Diabetic kidney disease (DKD) is found in up to 50% of adults with type 2 diabetes. People with DKD often have a high co-morbid burden which is associated with increased frailty and reduced health related quality of life (HRQOL). This increased risk highlights the need for strategies to prevent these patients from progressing into a state of increased physical dysfunction. We hypothesized that participation in a 6-month resistance exercise program in adults with DKD would result in improvements in functional outcomes (short physical performance battery assessment [SPPB], hand-grip), frailty status (Edmonton Frail Scale), HRQOL (SF-36) and health literacy.  We further hypothesized that adults with DKD with higher health literacy at study entry would experience the greatest improvements in functional outcomes, frailty and HRQOL.

Methods: An open-labelled, double block randomized controlled trial was conducted in adults aged 50 – 80 years with DKD (CKD stages I-IV) who were screened at baseline for frailty using the Clinical Frailty Scale. Participants attended baseline and 6-month visits at the Clinical Research Unit with monthly home/virtual visits. Participants were randomized into intervention (resistance exercise + nutrition literacy) or standard of care (physical activity + nutrition education based on Canadian guidelines).

Results: Frail intervention participants had significant percentage change in functional outcomes (balance [40%], sit-to-stand [38.5%], SPPB [23%], hand-grip [32%]), frailty status (Edmonton Frail Scale [-41%]) and HRQOL (bodily pain [30.6%], physical component scores [16%]). Non-frail intervention participants saw significant percentage change in sit-to-stand (33%) and SPPB (11%).  Higher HL was associated with improvements in sit-to-stand and SPPB for both frail and non-frail intervention participants (p<0.01).

Conclusions: Improvements in functional outcomes, frailty status and HRQOL in response to exercise are important as reduced functional performance and HRQOL is associated with adverse clinical outcomes.